Coxiella Pathogenesis and Effector-Effector Interplay

Intralysosomal pathogens differentially influence the proteolytic potential of their niche

LE Bird, B Xu, DR Thomas, ENS McGowan, P Newton, NE Scott, MJ McConville, LE Edgington-Mitchell, HJ Newton

2026-02-01

Avoiding lysosomal degradation is vital to the success of intracellular pathogens. The Gram-negative bacterium Coxiella burnetii a..

The complete genome sequence of the crayfish pathogen Candidatus Paracoxiella cheracis n.g. n.sp. provides insight into pathogenesis and the phylogeny of the Coxiellaceae family

DJ Ingle, CJ Walsh, GR Samuel, RR Wick, N Davidovich, E Fiocchi, LM Judd, J Elliman, L Owens, TP Stinear, A Basso, T Pretto, HJ Newton

2025-04-01

The Coxiellaceae bacterial family, within the order Legionellales, is defined by a collection of poorly characterized obligate int..

Coxiella burnetii manipulates the lysosomal protease cathepsin B to facilitate intracellular success

LE Bird, B Xu, AD Hobbs, AR Ziegler, NE Scott, P Newton, DR Thomas, LE Edgington-Mitchell, HJ Newton

2025-01-01

The obligate intracellular bacterium Coxiella burnetii establishes an intracellular replicative niche termed the Coxiella-containi..

Genomic epidemiology and phenotypic characterisation of Salmonella enterica serovar Panama in Victoria, Australia

Samriddhi Thakur, Sarah L Baines, Cheryll M Sia, Mary Valcanis, Louise M Judd, Benjamin P Howden, Hayley J Newton, Danielle J Ingle

2024-11-01

Salmonella enterica serovar Panama, a causative agent of non-typhoidal salmonellosis (NTS), is one of several serovars that causes..

Coxiella burnetii protein CBU2016 supports CCV expansion

DR Thomas, SE Garnish, CA Khoo, B Padmanabhan, NE Scott, HJ Newton

2024-01-01

Coxiella burnetii is a globally distributed obligate intracellular pathogen. Although often asymptomatic, infections can cause acu..

Eat, prey, love: Pathogen-mediated subversion of lysosomal biology

LE Bird, LE Edgington-Mitchell, HJ Newton

2023-08-01

The mammalian lysosome is classically considered the 'garbage can' of the cell, contributing to clearance of infection through its..

Macrophage infectivity potentiator protein, a peptidyl prolyl cis-trans isomerase, essential for Coxiella burnetii growth and pathogenesis

AW Debowski, NM Bzdyl, DR Thomas, NE Scott, CH Jenkins, J Iwasaki, EA Kibble, CA Khoo, NJ Scheuplein, PM Seibel, T Lohr, G Metters, CS Bond, IH Norville, KA Stubbs, NJ Harmer, U Holzgrabe, HJ Newton, M Sarkar-Tyson

2023-07-01

Coxiella burnetii is a Gram-negative intracellular pathogen that causes the debilitating disease Q fever, which affects both anima..

Coxiella co-opts the Glutathione Peroxidase 4 to protect the host cell from oxidative stress–induced cell death

RK Loterio, DR Thomas, W Andrade, YW Lee, LL Santos, DPA Mascarenhas, TM Steiner, J Chiaratto, LF Fielden, L Lopes, LE Bird, GH Goldman, D Stojanovski, NE Scott, DS Zamboni, HJ Newton

2023-01-01

The causative agent of human Q fever, Coxiella burnetii, is highly adapted to infect alveolar macrophages by inhibiting a range of..